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Background and Objective: Free radical production andsubsqunt oxidative steress can be due to hyperglycemia and its oxidation. This study was done to evaluate the effect of swimming training test and Fenugreek seed extract on plasma glucose and antioxidant activity in heart tissue of streptozotocine – induced diabetic rats. Methods: In this experimental study, 50 male wistar rats were allocated into five groups diabetic (DC, n=10), healthy control (HC, n=10), swimming training (S, n=10), swimming training + Fenugreek seed extract (1.74 g/kg/bw) (SF1, n=10), and swimming training + Fenugreek seed extract (0.87 g/kg/bw) (SF2, n=10). Streptozotocine (60 mg/kg/bw) was used for induction of diabetes in DC, S, SF1 and SF2 groups. Serum glucose and the rat heart tissue antioxidant enzymes activities of superoxide dismutase, Catalase and Glutation peroxidase were determined. Results: Body weight in all groups were significantly reduced in comparsion with healthy control group (P<0.05). Plasma glucose level significantly reduced in SF1 and HC groups compared to diabetic group (P<0.05). Cardiac antioxidant enzymes in swimming training, SF1 and SF2 groups significantly increased in compare to diabetic group (P<0.05). Conclusion: The combination of endurance swimming training and fenugreek seed extract can reduce plasma glucose and increase cardiac antioxidant enzymes in streptozotocine – induced diabetic rats.

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Background and Objective: Homocysteine and atherogenic index are significant and independent risk factors for cardiovascular diseases. This study was done to determine the effect of 10 weeks endurance swimming training on serum homocysteine level and atherogenic index in rats.

Methods: In this experimental study, 20 adult male Wistar rats (180±20 g) were randomly allocated into control (n=10) and experimental (n=10) groups. Animals in experimental group swam ten weeks of endurance training (5 days a week, for 60 minutes a day) with a 5% body weight load attached to the tail. At the end of 10 weeks and after the last of training session and 12 hours of fasting animals were sacrificed. Blood samples were taken and serum homocysteine level, atherogenic index and
NON-HDL-cholesterol were measured.

Results: Serum homocysteine level, atherogenic index and NON-HDL-cholesterol of animals significantly reduced in the experimental group compared to the controls (P<0.05).

Conclusion: Ten weeks of endurance swimming training with low to moderate intensity improves homocysteine level and atherogenic index in animal model.