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Anti-neutrophil cytoplasmic antibody (ANCA) are produced against lysozomal constituents and primary granules of myeloid cells (Neutrophiles & monocytes) in some rheumatic diseases and wegner’s granulomtosis (WG). This antibodies not only may related to onset of vasculitis lesions, but also have a valuable diagnostic tool, thus, first we tired to evaluated the prevalence of this antibodies in 65 serum of patients with RA and 42 serum of patients with SLE. By using of indirect immunoflourescence assay (IFA), two staining patterns are recognized: Cytoplasmic (C-ANCA) pattern which in 80% of results from anti-PR3, and prenuclear (P-ANCA) pattern, which can result from any antibody directed to myeloperoxidase (MPO), cathepsin G (CG) lactoferrin (LF), elastsae (HLE) and lysozyme (LZ). The sensitivity and specificity for SLE from 1:128 serum dilution was 8% and 85.1% respectively, and for RA from 1:16 dilution was 32.2% and 87.5% respectively. Of the 19 SLE, ANCA positive patients 18 (94.7%) had P-ANCA and 1 patient (5.3%) had C-ANCA and of the 23 RA, ANCA positive patients, 17 (73.9%) had P-ANCA and 6 patients (26.1%) had C-ANCA.

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Due to importance of menopause and it’s effects on the menopausal women, and also the use of hormonal replacement therapy, we decided to evaluate side effects of Estrogen therapy on menopausal women, such as sleep disorder and related problems. 60 menopausal women entered a 3-months prospective, placebo-case controlled, double blind and accidental study. They were selected after taking history and physical examination, some necessary laboratory data, exclusion of interfering factors. They were divided in 2 groups with equal members. Conjugated Estrogen (0.625 mg per day) was given orally for 3 months to case group. Placebo (1 tablet per day) was given to control group. The 2 groups evaluated again after 3 months. A questionnaire with 7 questions was given to the members of 2 groups before and after treatment. Treatment with Estrogen reduce number of sleep awakening, daily drawsiness, morning tiredness and improve the sleeping and resleeping (P<0.05) and with confidence interval of (95%). In our study, there was not significant correlation between weight, age, duration of menopause, cause of menopause with sleep disorders. According to this study, we conclude that Estrogen replacement therapy reduce sleep disorders in post menopausal women. These findings confirm HRT benefits.

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The sleep is one of the important phenomen in biological rhythm. Sleep function are usually characterized as being physical and emotional protective and restorative. On the average people spend a third of their life in sleep, and people up to 30% of population suffer from sleep disorders. Sleep disorders are major psychiatric problems. This is a descriptive survey for studying sleep disorders (Insomnia, excessive somnolence, functional disorders) among nurses working at hospitals affiliated with Shahid Beheshti’s Medical Sciences University in this study 751 nurses aged between 20-45 years have participated by data collection using questionnaire and analysis by tests, the results indicated, the most of sleep disorders in insomnia (Initiating sleep 55.8%, maintaining sleep 72.4%, early awakefulness 52.7%, excessive somnolence 65.5% and parasomnia 26.9%). In additional, there has been significant correlation between the demographic factors such as age, sex, marriage, shiftwork, with sleep disorders. These results conclude that the presence of different kind of sleep disorders among the nurses is the indicator of relation between the nurse job with biological disorder of sleep ryteme.

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Background and Objective: Nightshift working has negative physical, psychological and social effects on personal life of nurses and in the long run, with subsequent health and complication. This survey was done to study the effect of sleeplessness on general health of nightshift nurses in hospitals of Golestan University of Medical Sciences, Gorgan, Iran, during 2008. Materials and Methods: In this descriptive study, 124 subjects with suitable condition were selected through a census from among 615 nightshift working nurses in hospitals of Golestan university of medical sciences. Data were collected by delivering questionnaire and it included one questionnaire of personal information and two questionnaires about effects of sleeplessness and general health (GHQ-28). Results: Effect of sleeplessness, in the maximum percent of nurses (55.6%) were moderate and in the minimum percent (2.4%) were low. Mean±SD the sleepness rate was moderate (58±9). Also, the results of general health showed that most of them (60.6%) had favorable general health and 2.5% of subjects had unfavorable general health. There was a significant correlation between sleepness, effect and general health of nurses in addition. There was also a meningfull sleeplessness correlation between sleepness effect with age, employment history and nightschieft time table (P<0.05). Conclusion: This study showed that sleepness, negatively, effect on general health of nightschieft nurses, it is suggested, there should a properly organized sleep time table for the nightchieft nurses.

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Background and Objective: Several investigations have indicated the antinociceptive, anti-inflammatory, antipyretic effects and smooth muscle relaxant activity of Cassia species. This study was done to determine the effect of Cassia fistula on sleeping time and the level of anxiety in mice. Materials and Methods: In this experimental study, 80 male albino mice (25-30 g) randomly allocated in 8 groups. For measuring the sleeping time we used the Angle method and animals were divided into three experimentals (250, 500 and 1000 mg/kg) and one control group. For evaluating of anxiety levels, animals randomly were divided into three experimentals and one control group, and elevated plus maze (EPM) model was used. The evaluation of anxiety indices included number and percent of time spent in open arm. Different doses of the aqueous extract of Cassia fistula (250, 500, 1000 mg/kg IP) were injected intraperitoneally to the treated groups. Controls were recived 10 ml/kg/BW normal saline intraperitoneally in both methods. Results: The extract of Cassia fistula (250, 500 and 1000 mg/kg) significantly increased sleeping time [F (3, 39)=23.19, P<0.05]. Also open time [F (3,39)=15.55, P<0.05] and the number of open arm entries [F (3, 39)=24.21, P<0.05] were significantly in doses (250mg and 500 mg) were singnificantly more than control group, respectively (P<0.05). Conclusion: This study showed that the aqueous extract of Cassia fistula fruit incerase the sleeping time and deereasing level of anxity in mice.

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Background and Objective: Poor sleep quality is common among hemodialysis patients and can potentially predict morbidity, mortality and quality of life in these patients. On the other hand, hemodialysis patients are encountered with vitamin C deficiency. The purpose of this study was to determine the effect of intravenous vitamin C on sleep quality in hemodialysis patients.

Materials and Methods: In this double blind randomized clinical trial, 60 qualified hemodialysis patients were gone under investigation in Sari a city located in North of Iran during 2010. Patients randomly allocated in two equal intervention and control groups. The main measured outcome was the Pittsburg sleep quality index (PSQI) which consists of seven components. At the end of each hemodialysis session, Intervention group received vitamin C vial (500mg/5cc) intravenously, three times a week for 8 weeks and control group received normal saline in a same way. Data were collected at pretreatment and after two months of treatment. Data were analyzed by Independent t test, Paired t test, Wilcoxon and Chi-Square tests.

Results: The result indicated that the sleep quality improves significantly in vitamin C group but not in control group (P<0.001). Vitamin C caused significant improvement in subjective sleep quality, sleep latency, habitual sleep efficiency and sleep disturbances in intervention group (p<0.05). Also, Global PSQI score of intervention group had a greater improvement than control group. Moreover vitamin C caused significant improvement in subjective sleep quality, sleep latency, habitual sleep efficiency and sleep disturbances in intervention group after treatment (p<0.05).

Conclusion: This study showed that intravenous vitamin C can effectively improve sleep quality in hemodialysis patients.

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Background and Objective: Sleep disurbance is considered to be one of the most common problems in menopausal women. Herbal supplements are being used as herbal supplemental medication to solve the problem. The aim of this study was to determine the effect of Sedamin capsule on sleep disorder among menopausal women. Materials and Methods: This randomized controlled trial study was done on 100 Menopausal women aged 50-60 with sleep disorder. Women randomly divided into intervention and contol groups. Subjects intervention group were received Sedamin capsule (530 mg Valerian root) twice a day for 30 days. Women in control group were received capsule (50 mg of carbohydrate) twice a day for 30 days. Demographic data form and Pittsburg sleep quality index was instrumented for the evaluation of disorder. Data analyzed with using independent T and ANOVA tests. Results: Mean score of sleep disorder peior and after intervention was 9.8±3.6 and 6.02±2.6 (P<0.05) in interventional group and 11.14±4 and 9.4±3.9 in controls, respectively. Also, 40% of the participants in the intervention group and 12% in the control group showed an improvement in the quality of sleep (P<0.05). Conclusion: This study showed that consumption of Sedamin capsule improves the quality of sleep in menopausal women with sleep disorder.

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Background and Objective: Occurrence of nursing error is important issue in patients safety. This study was done to determine the role of workload, sleep, mental health and individual factors in occurrence of nursing errors. Materials and Methods: This descriptive study was done on 268 nurses who employed in hospitals of Tehran University during 2011. Data were collected by demographical information questionnaire along with work environment conditions, Global Sleep Assessment Questionnaire (GSAQ), Pittsburgh Sleep Symptom Questionnaire (PSSQ) and Mental Health Inventory (MHI-28). Results: Sleep distruptions (OR=3.260, P<0.002), sleep behaviors (OR=2.946, P<0.003), psychological distress (OR=2.530, P<0.006), psychological well-being (OR=0.775, P<0.002), and work overload (OR=5.240, P<0.009) significantly able to predict occurrence of nursing errors (P<0.05). Conclusion: Work overload, sleep distruptions, sleep behaviors, psychological distress and psychological well-being cooperatively were resulting in occurrence of nursing errors.

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Background and Objective: Attention deficit and hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder in childhood. 20-50% of ADHD affacted children have sleep disorders which can cause cognitive and behavioral disorders. This study was done to determine the sleep problems in children with ADHD. Method: In this case control study, 52 children with ADHD was considered as cases and 52 school age children without ADHD as a control group in Gorgan, northern Iran during 2013. Sleep habits (CSHQ) and DSM-IV questionnaires were filled for each child. Results: Sleep problems were observed in 45 (86.5%) and 36 (69.2%) of children in case and control group, respectively (P<0.05). The mean score of sleep problems in case and control group was 48.25±6.61 and 45.87±6.23, respectively (P<0.05). The score of resistance to sleep, anxious habits of sleep and waking during night in cases were more than controls (P<0.05). Conclusion: Sleep problems in children with ADHD are more frequent than children without ADHD.

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Background and Objective: Somatic and psychological altrations during menopause have negative impact on quality of life. This study was done to evaluate the effect of Aphrodit on somatic symptoms in postmenopausal women. Methods: In this clinical trial study 63 menopausal women were randomly divided into intervention and control groups. Subjects in interventional group were received Aphrodit capsule (40 mg of Tribulus terrestris fruits, 12.27 mg ginger, 33 mg saffron and 11 mg of cinnamon) for four weeks. Somatic symptoms of menopause (including hot flashes, night sweats and tachycardia) and sleep disorder and muscluskeletal disorder were evaluated using Menopause Rating Scale. Results: After intervention, the mean of hot flash score in interventional and control groups was 1.29±0.1 and 3.1±0.6 (P<0.05).The mean of sleep disorder score in interventional group and controls was 1.82±0.2 and 2.82±3.1 (P<0.05). The mean of muscluskeletal disorder score in interventional group and controls was 1.03±0.1 and 2.81±1.2 (P<0.05).There was no diference in the heart problem score between interventional and control groups. Conclusion: Consumption of Aphrodit capsule reduces hot flash, sleep disorder and muscluskeletal disorder in postmenopausal women.

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Background and Objective: Sleep is an important component of the circadian cycle is associated with the restoration of the physical and mental faculties. Physical activity is one of the confounding factors in improving sleep quality. This study was done to determine the effect of physical activity on quality of sleep in female students.

Methods: This cross-sectional study was conducted on 370 female students in Zabol University in south-east of Iran. Demographic data through a questionnaire were collected for each subject. Sleep quality and physical activity of subjects were recorded using standardized questionnaire Pittsburgh sleep quality index (PSQI) and physical activity Beck test. Subjects according to physical activity divided into active and inactive groups.

Results: Poor sleep quality was seen in 25.2% and 67.4% of active and inactive students, respectively. Mean of Sleep quality in both groups active 5.73±3.22 and inactive  7.21±3.75 was inappropriate but sleep quality in active females was higher than inactive females (P<0.05). A favorable condition for the quality of sleep was seen in 65.7% of the active group with BMI<25 and only 9.1% of students BMI was more than 25. In inactive students, 60.8% of subjects with BMI<25 had poor sleep quality. Both levels of BMI, sleep quality was significantly different between the groups, but this difference was higher in the active group (P<0.05).

Conclusion: Poor sleep quality was seen in high percentage of female students and physical activity influences the quality of sleep.

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Background and Objective: Changing of lifestyle in women and increasing their social activity especially in working places can affect women’s sexual quality of life (SQOL). This study was done to determine the affecting factors on sexual quality of life among hospital employee's women.

Methods: This descriptive - analytical study was carried out on 121 women who work in the two hospitals in Sabzevar city and Birjand city in Iran during 2014. Data was collected using two questionnaires including the Iranian version of sexual quality of life-female (SQOL-F) questionnaire and a researcher-made measure to assess demographic characteristics, health related, and work-related variables.

Results: The mean±SD score of SQOL-F was 80.1±19.7. The univariate analysis showed that the mean score of SQOL-F significantly related with age (P<0.05), duration of sleep (P<0.05), marital duration (P<0.05), educational level (P<0.05), and physical activity (P<0.05). The regression modeling indicated that educational level (β=0.33), marital duration (β=0.32) and quality of sleep (β=0.56) were predictors of SQOL-F scores.

Conclusion: This study showed that educational level, marital duration and quality of sleep were predictors of SQOL-F scores among hospital employee's women.

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Background and Objective: Chronic hypertrophy of tonsils and adenoids is the most prevalent cause of sleep apnea in children, leading to multiple behavioral disorders. Attention deficit hyperactivity disorder (ADHD) is a heterogeneous disorder caused by adverse biological, social and psychological conditions. This study aimed to evaluate the effect of adenotonsillectomy on ADHD symptoms in children with adenotonsillar hypertrophy before and six months after the surgery.
Methods: This descriptive-analytical study was performed on 37 children with adenoid hypertrophy in Gorgan, north of Iran during 2018. The data gathering tool was a two-part questionnaire; the first part contained personal data (age, gender), and the second part included the strengths and difficulties checklist. Patients were placed in three groups of hyperactivity, inattention and impulsivity based on 18 criteria of Diagnostic and Statistical manual of Mental disorders. The questionnaires were completed directly by the project performers. Information was collected from the parents. The strengths and difficulties questionnaire (SDQ) was used to assess children before and six months after the adenotonsillectomy surgery.
Results: The average and standard deviation of scores in subscales of emotional symptoms, conduct problems, hyperactivity-inattention, peer relationship problems and prosocial behavior were improved, also a significant difference was observed between SDQ scores before and after adenotonsillectomy (P<0.05).
Conclusion: Adenotonsillectomy can significantly reduce the SDQ score. Therefore, in children with hyperactivity, a medical disorder such as adenoid hypertrophy can cause the onset, exacerbation and persistence of the disease. Proper treatment can be a major factor in controlling the severity of symptoms and even in improving the patient’s recovery.

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Background and Objective: The widespread use of digital devices by children has become a significant threat to global health. This study was conducted to evaluate the correlation among screen time, sleep quality, and overweight in preschool children.
Methods: This descriptive-analytical study was conducted on 100 preschool children (46 boys and 54 girls) aged 3 to 6 years and their parents in the city of Qazvin, Iran during 2019-2020. Data were collected using interviews and the Factors Associated with Screen Time in Iranian Children and Adolescents Questionnaire (Mozafarian et al., 2017).
Results: Seventy-six percent of the children were the firstborn in their families. The mean cumulative screen time for the children was four hours per day. Fifty percent of the parents did not adequately supervise their child’s television screen time at home. A statistically significant positive correlation was found between body mass index (BMI) and television screen time duration (r=0.24, P=0.01). With an increase in the children’s cumulative screen time, a statistically significant decrease was observed in the child’s sleep duration (r=−0.21, P=0.04). Although mothers had a significantly higher mean screen time compared to fathers (P<0.001), children’s television screen time exhibited a statistically significant correlation with their fathers’ television screen time (r=0.23, P=0.002).
Conclusion: The mean screen time for preschool children is high. Furthermore, the mean screen time is associated with children’s decreased sleep duration and increased BMI.