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In order to determine the relationship between breast feeding and growth pattern, the information about anthropometric measurement and feeding pattern in first 4-6 months of life and after that of 324 hospitalized children were recorded and analyzed results are as follow: 67.3% were exclusively breast-fed, 61.3% were breast-fed accompanied with non-maternal milk (Cow milk, formula, pasteurized cow milk) and 11.4% were fed with non-maternal milk only. 44.8% of the total patients had weight for the age under 5th percentile, 53.7% had height for the under 5th percentile and 26.9% had head circumference (HC) for age under 5th percentile of NCHS standard. 77.8% of infants under 6 months of age who had weight for age under 5th percentile never have been fed with breast milk. In the other hand 72.2% of patients with weight for age between 5-100th percentile fed exclusively with breast milk in first 4-6 months of life (P<0.03). 63.2% of infants aged 6-12 months with weight for age under 5th percentile have never been fed with breast milk in first 4-6 months or did not commence supplementary food on time. This study suggest that exclusively breast-feeding in first 4-6 months of life and continuation of breast milk beside supplementary food on proper time can provide better growth potential relative to other options.

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In this research we examined the sensitivity of micronucleus assay for monitoring clastogenic effects of low dose fast neutrons. Syrian mice (12 weeks old) were irradiated by fast neutrons emitted from a 241Am-9Be source. The absorbed dose was 1.5, 2.25, 3.375 and 5.06 cGy. Mice were scarified by cervical dislocation at different post irradiation times (24, 48 and 72 h). The results obtained show that the frequency of neutron-induced micronuclei in polychromatic erythrocytes (PCES) is significantly higher than those of control groups (P<0.05) at neutron dose used in this experiment. We concluded that micronucleus assay is an effective and also inexpensive method for monitoring clastogenic effects of high LET radiation in low dose levels.

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Breast cancer is the most common cancer in women. Histologic grading is one of the prognostic factors in breast cancer. The present study performed in analytic descriptive method and based on the slide review of beast biopsies received in the pathology department of 5th Azar Hospital from 1976 to 1978, and on the basis of Bloom-Richardson criteria (Mitoses, tubule formation and nuclear pleomorphism). The results are consist of: 1) Infiltrating duct carcinoma is the most common histopathologic form, and tubular carcinoma is the least common 2) The most common age is 36-45 years 3) There is meaningful relationship between mitoses and tubule formation and between pleomorphism and tubule formation. But there is no relation between nuclear pleomorphism and tubule formation in the tumor. Histologic grading of breast carcinoma should be reported by pathologist for clear determination of prognosis and also the best choice for management of the tumors.

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Pseudoxantoma Elasticum is a hereditary disease with prevalency of 1 among 160000 people in which yellowish papules and plaques are symmetrically distributed in abnormally lax skin of the neck, axilla, groin, and cubital and popliteal spaces, other parts of the body are less frequently involved. Patient that has been presented is 30 years old Turkman woman referred to 5th Azar Hospital with skin problems contains skin folds at neck, yellowish papules at ant, abdomen, cubital area and neck. After skin biopsy, histopathological findings confirmed clinical diagnosis of Pseudoxantoma Elasticum.

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Diarrhea and malnutrition are important health problems in human societies, especially in developing countries, leading to a huge number of deaths annually. Numerous studies have death with the relationship between malnutrition as a predisposing factor and acute diarrhea, but they have yielded conflicted results. In a cross-sectional controlled study, we examined 398 infants 1-24 month-old referred to the diarrhea-training unit (DTU) of hospital. After treating dehydration, height, weight were measured and compared with an age-matched control group. In cases with acute diarrhea, 3.2% had severe, 14.8% had moderate, 48.8% had light malnutrition, 33.2% had no malnutrition according to Gomez scale. In the control group, the percentage of subjects with severe, moderate, light, and with out malnutrition were 0.5%, 2.2%, 32.4%, and 64.8%, respectively. Average weight for age and weight for height scores were significantly lower in cases with acute diarrhea than in control subjects. However, average for age score was not statistically different in the 2 groups. Patients with acute diarrhea suffered a higher prevalence of malnutrition compared with those from the control group. There was not statistically significant relationship between growth indices and socioeconomic class of the family. A lower percentage of infants with acute diarrhea compared with control group enjoyed breast-feeding as the primary feeding routine. The period of breast-feeding was shorter in infants with acute diarrhea. Nevertheless, breast-feeding neither have significant effects on malnutrition nor on weight and height growth indices. Overall, we concluded that malnutrition and decreased weight growth index might be important predisposing factors for acute diarrhea. Early diagnosis and treatment of malnutrition (Especially moderate and light degrees) are very important measures to be taken in order to decrease diarrhea and its complications.

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Diabetes mellitus is a common metabolic disorder that is associated with long-term complications of various organs, such as cardiovascular system. This study is about evaluation of myocardial function and determination of related cardiovascular factor in type 2 diabetic patients who referred to diabetes clinic of 5th Azar Hospital from 200 patients who referred to the clinic, 48.5% had diastolic and 29.5% had systolic dysfunction. Related factors with both diastolic and systolic dysfunction of diabetic patients are: HbA1c level (Control of diabetes), duration of diabetes and hypertension. This investigation shows that: Incidence and severity of systolic and diastolic dysfunction in type 2 diabetic patients are related to metabolic state and quality of diabetic control. Incidence of hypertension increase in diabetic patients, and hypertension is an important risk factor in diastolic and systolic dysfunction. Diastolic dysfunction is more common than systolic dysfunction in diabetic patients. Intensive control of blood Glucose level lead to decreasing the incidence of coronary artery disease in diabetic patients. We suggest, intensive control of blood Glucose level, treatment of hypertension, regular cardiovascular evaluation in diabetic patients and screening test for early diagnosis of diabetes in high-risk population should be taken under consideration.

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The cancer of breast is the most common malignancy among women and after cancer of the lung is the second cause of death in females. Thus, early diagnosis and treatment can have a effect significant in prognosis and clinical course of disease. One of the numerous controversial tissues to the clinical management of breast cancers is the role of fine-needle aspiration (FNA) to assess the accuracy and determine the role of FNA in breast cancer diagnosis, we performed both FNA and excisional biopsy in 86 unselected patients with palpable breast masses and correlated the cytologic and histopathologic findings. In our study, FNA had no false-negative and no false-positive results, and the sensitivity of diagnosis of malignant tumors was 88.8%, the specificity of diagnosis of benign lesions was 96.2% and the predictive values were 100%, respectively. On the basis of above study, breast FNA may add a measure of confidence in the diagnosis of benign lesions, provides a safeguard for preventing misdiagnosis of malignant lesion, and might expedite and reduce the cost of managing breast cancer. Also, breast FNA like any diagnostic method depends to individual techniques and continual practice.

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Perichondritis and chondritis are rare disease of auricle than may be due to burns surgery or trauma and can present with severe pain erythema and edema. Herpes Zoster, that is due to reactivation of virus in nerve root that present with vesicular group in erythematous fild cranial or spinal nerve innervated zone can present with sever pain and some factors include stress-chemotherapy and really surgery can facilate activation of them. We report a case with perichondritis-chondritis and herpes zoster that had reaction to chromic material after tympanomastoidectomy and with medical treatment and debridement with some sequela healed. The importance of this case is multipathological that can mislead the clinication.

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The present research is a descriptive and analytical study, which is done in order to investigate the reasons of failure in exclusive breast-feeding in Gorgan. 322 women with children between six to 12 months who referred to health center in Gorgan were chosen as convenience sampling. The instruments for collecting information were some questionnaires included open-ended or closed questions, which was related to individual, social and familial characteristics of parents and children. The findings showed that only 44.4% had exclusive breast-feeding. The most current additional liquid in 59.9% was Glucose water. The most important reason for beginning the additional nutrition was colic which most of the time was advised by grandmother (32.6%). Chi-square has shown maternal age, mother’s conception of her ability in breast feeding, feeling that she would not have enough milk to adequately nourish her baby child, acute diseases, the low birth weight and among the reason for failure to have exclusive breast feeding (P<0.05).

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Breast cancer is one of the most common causes of death due to cancer in women. More than half of hereditary breast/ovarian cancer families could be attributed to mutation in breast cancer susceptibility gene BRCA1. This study was performed on blood samples of 30 women who affected with familial breast cancer. Non-radioactive PCR-SSCP technique was utilized mutation screening in exons 3, 10, 12 of BRCA1 gene. Two shifts in exon 3 and also two in exon 12 was detected, but no shift in exon 10 was found. Due to low number of recognized mutations, the statistical analysis didn’t show a meaningful correlation between mutations and pathological characteristics. Results from this study showed that there was a low possibility of germline mutation in these three exons. Low rate of mutation in this report was concordance with the others.

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The solid waste is all of the refuse produced by the human activities. The quality and quantity of the solid waste are variable according to the economic, social and cultural factors. The purpose of this research is to study of the quality and quantity of the Gorgan garbage. This is a cross-sectional study. We used the city halls statistics to calculate the share-out of the garbage (Daily produced garbage divided by the population of the city in that year). This share-out is calculated in spring and fall in 1998. To determine the quality of garbage, the city was divided to three zones: Northern, central and southern zone. Two temporary container were chosen in each zone and 100 kg garbage were taken from each container. The garbage of each container was examined three times during each season. After separating the samples out, the rates are reported according to the percentage of the weight of various materials. The final results shown are the mean of results that came from the study of the chosen containers. The results show that the share-out of garbage for one person in spring is 537 gr and in fall is 644 gr. According to their weight, the percentage of various materials were: Biodegradable materials 85.6%, paper and carton 6.6%, glass 2.6%, plastic 2%, fabrics and cloths 1.5%, wood 0.9% and metals 0.8%. This study reveals that biodegradable materials are the majority of garbage. To establish the compost industry in this province and use the prepared compost in agriculture can decrease the need for chemical fertilizer, and the same time, environmental pollution by both chemical and biodegradable materials would reduce.

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Major histocompatibility complex (MHC), which plays a major biological function in immune response, is generally associated with so many human disease. During recent years a new clinical relevance of MHC disease. On the other hand there is a strong correlation between some autoimmune diseases and MHC system such as in some allergic abnormalities and its relation with HLA antigens. In order to investigate this concept 30 atypic asthmatic patients and 100 healthy controls were selected. Human leukocyte antigen (HLA) typing was performed by standard NIH procedures and the results analyzed. The frequency of HLA-A2, A11, Aw19 and HLA-B51 decreased in atypic asthmatic patients with no association recorded significantly between HLA-C and allergic asthma. The results of our study indicated that there was a significant relationship between allergic asthma and HLA-I antigens.

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Diarrhea is one of the main reasons of mortality among children in the developed countries and half of all death is due to persisted diarrhea. This research is a cross-sectional and analytical study done on 708 children with acute diarrhea in village around Gorgan, to find out the effective factors on having persisted diarrhea in children under 5 years old. Face to face interview and determining the variable factors and examining health center records on children with acute diarrhea were the basis for filling the corresponding questionnaires. 14 days after the start of acute diarrhea, which was the second part of this research, the above questionnaires were fully completed by calling on the patient’s home. According to our investigation the risk factors related to the persisted diarrhea were as follow: Age, ethnicity, children length of breast feeding, chlorinated water, children consumed food at the time of acute diarrhea. The results from this investigation indicate that with 95% about probability 10.7%-11.3% of patients with acute diarrhea end-up with persisted diarrhea, which means diarrhea, was continued for more than 14 days. Therefore by controlling the above risk factors the mortality rate due to acute diarrhea could be reduced.

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Background and Objective: After distinguishing the role of Helicobacter Pylori in gastritis and peptic ulcer, some hypothesis were brought up about the probable interference of this germ in dyspepsia. This study was done in order to determine the prevalence of Helicobacter Pylori infection in persons conflicted with dyspepsia, attended in 5th Azar Hospital in Gorgan during 8 months (From 2001/Mar/21 to 2001/Nov/22). Materials and Methods: In this research, 270 patients with diagnosis of dyspepsia were endoscopic based on clinical examinations and paraclinical studies and after ruling out of erosive gastrodeodenitis and peptic ulcer, two biopsy samples were taken from antrum. Then, the samples were put in urea rapid test environment media. The required time for positive response was 15 minutes but to be completely sure about it, urea environment media consisted of biopsy samples were maintained for 2 hours. Any color changes during this time were considered as positive response. Results: Among 270 patients conflicted with dyspepsia 136 patties were male and 134 were female with age average of 40.9% Y/O. The patients with Helicobacter Pylori infection were 139 (51.5%) and the ones without infection were 131 (48.5%), and age averages were 44.4 Y/O and 37.3 Y/O, respectively. The prevalence of dyspepsia subgroups were as follows: Ulcer like 53.7%, reflux like 31.1%, non specific 9.6%, and dismotility like 5.6%, and the prevalence of infection among dyspepsia subgroups were as follows: Ulcer like 62.02%, reflux like 40.47%, non specific 46.15%, and dismotility like 20%. Other risk factors in these patients were as follows: Cigarette smoking 25.6%, NSAID 16.3% and alcohol drinking 4.1%. Conclusion: This study suggests that Helicobacter Pylori infection can have a role in formation of dyspepsia.

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Cutaneous metastasis from carcinoma of the larynx are very rare. We observed a 75-year-old male patient with squamous cell carcinoma of the larynx who developed a subcutaneous nodule as an abscess presentation in the buttock. It was found to be a metastatic squamous cell carcinoma of the laryngeal cancer, histopathologically. The skin manifestations proceeded laryngeal metastases by 18 months after laryngectomy and radical neck dissection. After 3 months, the patient died. Cutaneous metastasis of laryngeal carcinoma should be considered in all patients with previous laryngeal carcinoma representing with cutaneous lesion.

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Background & Objective: Gastric cancer is the 2nd cause of cancer mortality after lung cancer. Approximately 12% of all cancer death are due to gastric cancer. Tumorgenesis is thought to be a multistep process involving a series of genetic changes in oncogenes and suppressor genes. The most common cancer-related genetic change known in human tumors is P53 mutation, particularly in gastric cancer. This study was done to determine P53 gene mutations in gastric cancer. Materials & Methods: This study was performed on 44 biopsy from patients with gastric cancer during 2002 in 3 hospitals in Tehran. For determination of P53 gene mutations was performed PCR-SSCP methods. Results: The patients group comprised 31 males and 13 females (Average age, 60.8 years Ranging from 34 to 84 years). 36 cases (81.8%) intestinal type, 5 cases (11.4%) were diffuse type and 3 cases no defined. 44 gastric cancers of gastric tissues were screened for the mutations of P53 gene mutations in exons 5-8 using the PCR-SSCP analysis. After polyacrylamide gel electrophoresis, 9 patients (20.5%) showed an apparent electrophoretic mobility shift between the cancer and other normal samples. One mutation in exon 5 (11.1%), 2 were detected in exon 6 (22.2%), 3 were found in exon 7 (33.3%) and 3 were detected in exon 8 (33.3%). The mutation rate was 7 of 36 (21.2%) in intestinal type and 2 of (40%) in diffuse type. No significant correlation between P53 gene mutations and age and genus was found. Conclusion: This investigation showed the rate P53 gene mutation (20.5%) in gastric cancer in our society.

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Background & Objective: Tuberculosis (TB) is still one of the most common causes of death in the world. The incidence of TB, included extra pulmonary variant has been increasing in developed countries for 2 past decades and also has a high incidence and prevalence in underdeveloped countries. To determine the type of involved organ by extra pleuro-pulmonary TB in Shahid Beheshti Hospital in Babol, the present study was carried out. Materials & Methods: Pathological reports of extra pleuro-pulmonary TB in Babol Shahid Beheshti Hospital during performed 1990-2003 have been studied. Sex, age and involved organs were determined, and subsequently the appropriate table was set up. Results: During 14 years, we diagnosed 82 cases of extra pleuro-pulmonary TB, 44 were men and 38 women, with age ranges of 8 months-79 years. TB lymphadenitis was the most common form (45 cases), followed by soft tissue 14 cases, bone 4, intestine 3, and 2 cases for endometrium, skin, testis and epididymis, and one case for ovary, tonsil, larynx, prostate, parotid gland, synovium, stomach, and kidney. The diagnosis was confirmed by presence of acid-fast bacillus in tissue section by Ziehl Neelsen staining and good response to anti-TB treatment. Conclusion: Although the TB lymphadenitis was the most common type, but in regions with high rate of TB, considering extra pleuro-pulmonary TB in unusual clinical setting is important and using appropriate diagnostic procedures and treatment if it is necessary.

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A 70- years old female referred with left upper quadrant pain since about 72 hours prior to hospital admission. In physical examination the patient was pale, hypotensive, tachycardiac and a vague left upper quadrant (LUQ) mass palpated. LUQ mass and free intraperitoneal fluid declared by ultrasound investigation there was no history of abdominal trauma and with impression of intraabdominal bleeding of unknown origin the patient underwent laparotomy. A huge fundal gastric mass identified with surrounding rupturea retroperitoneal hematoma and intraperitoneal hemorrhage. No intragatric penetration or hemorrhage was seen, so complete excision of the mass with safe margin was done with subsequent splenectomy. She had an uneventful post operative course and was discharged at the 7th post- op day. A microscopic analysis of the excised tumor demonstrated gastric leiomyoma.

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Background & Objective: WHO estimated almost 27% of under 5 years children suffered from under-weight. This study aimed are assessing anthropometric indicators (underweight, wasting and stunting) in 0-24 months children at Golestan province and the relationship with the background variables of households. Materials & Methods: This cross-sectional study was done on 1473 children (under 2 years old) whom resided in urban and rural area. Samplimg method was single stage cluster sampling. Constitutional variables in child’s mothers, age, educational level, job and child’s weight and height are measured by structured questionnair. The data were analysed with chi square, chi square for trend and logistic regression. Results: The under-weight, wasting and stunting (mild to severe) prevalence were 21.4% (CI 95%: 19.3-23.6), 16.5% (CI 95%: 14.7-18.5) and 31.4% (CI 95%: 29.1-33.8) respectively. Maximum sex difference in the malnutrition indicators were seen stunting (boys 14.3%, girls 7.2%) (p<0.05). The prevalence of under-weight, wasting and stunting are positively correlated with increasing the children’s age. The under-weight and stunting linear trend was significant (p<0.05). The risk of under-weight children were 2.8 fold in illitraced mothers relative to mothers with high school diploma (CI 95% for adjusted odds ratio: 1.1-7). The risk was 1.5 fold in stunting (CI 95% for adjusted odds ratio: 0.5-4.3). Conclusion: The under-weight and wasting (moderate to severe) prevalence are increased relatively ANIS study (1998), but stunting prevalence are not increased. The mothers’ illitracy and very low educational level can be suspected risk factors for under-weight and stunting.