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Showing 64 results for Ros
Ali Mikaeili , Sajjad Nasseri , Mohammad Mahdi Hosseini , Seyed Ahmad Emami , Mahdi Mojarrab ,
Volume 26, Issue 2 (7-2024)
Abstract
Background and Objective: Dermatophytosis is a significant skin disease in humans and animals, with increasing resistance to conventional treatments. This study aimed to determine the antifungal activity of petroleum ether, dichloromethane, ethyl acetate, ethanol, and hydroethanol extracts from the aerial parts of Artemisia khorassanica, Artemisia scoparia, and Artemisia vulgaris against common dermatophytic fungi, including Trichophyton rubrum, Trichophyton verrucosum, Epidermophyton floccosum, and Microsporum canis.
Methods: This descriptive study examined the antifungal activity of various extracts from the aerial parts of Artemisia khorassanica, Artemisia scoparia, and Artemisia vulgaris against fungal isolates of Trichophyton rubrum, Trichophyton verrucosum, Microsporum canis, and Epidermophyton floccosum. The aerial parts of the three Artemisia species were extracted using five solvents: petroleum ether, dichloromethane, ethyl acetate, ethanol, and 50% hydroethanol. The extracts were screened for antidermatophytic effects against the fungi mentioned above, and the minimum inhibitory concentration (MIC) was determined using the agar dilution method. The most active extracts underwent preliminary phytochemical testing.
Results: In the initial screening, Microsporum canis and Trichophyton verrucosum showed the highest sensitivity (86.66%) and resistance (100%) to the tested extracts, respectively. Extracts from Artemisia scoparia exhibited the broadest range of activity. The most effective extracts, with an MIC of 78.12 µg/ml, were also from this plant. Hydroethanol extracts from all plant species demonstrated the least antidermatophytic activity. Preliminary phytochemical studies revealed the presence of terpenoids in all petroleum ether and dichloromethane extracts of the plant species.
Conclusion: Some lipophilic compounds, particularly in the petroleum ether and dichloromethane extracts of Artemisia scoparia, exhibit significant in vitro antidermatophytic activity.
Maryam Abolghazi , Majid Shahbazi , Mohammad Jafar Golalipour ,
Volume 26, Issue 4 (12-2024)
Abstract
Background and Objective: Demyelinating lesions, widespread tissue damage, and neuronal connectivity impairments in white matter are associated with reduced cognitive decline in multiple sclerosis (MS) patients. These findings are particularly prominent in the corpus callosum of the brain. Interleukin-10 (IL-10) is an anti-inflammatory cytokine secreted by regulatory T cells (Tregs) with anti-inflammatory properties and can inhibit the production of pro-inflammatory cytokines produced by macrophages and T cells. IL-6 is a multifunctional cytokine involved in the immune system of autoimmune diseases. The IL-6 gene consists of 5 exons, 4 introns, and a proximal promoter region located on the 7p21 chromosomal locus in humans. This study aimed to determine the effects of IL-10 (-1082/-819) and IL-6 (-174) gene polymorphisms on corpus callosum changes in women with MS.
Methods: This case-control study was conducted on 40 women with MS aged 20-40 years referring to Golestan and Kowsar Magnetic Resonance Imaging (MRI) centers in Gorgan and 20 women without MS, autoimmune or inflammatory diseases over 40 years during 2015. Ten mL of blood was taken from the subjects for genotyping. Additionally, DNA extraction was performed using the phenol-chloroform method, and DNA genotyping was performed using the sequence specific primer-polymerase chain reaction (SSP-PCR) method. Brain MRI images of the subjects were employed to measure the corpus callosum and to investigate the relationship with the investigated polymorphisms.
Results: After performing the tests and obtaining different IL-6, IL-10 (-819), and IL-10 (-1082) genotypes, no significant statistical correlation was observed between IL genotypes in the case and control groups. Additionally, no significant correlation was observed between the different IL-6, IL-10 (-819), and IL-10 (-1082) genotypes and changes in the size of different parts of the corpus callosum, including rostrum width, splenium width, body width, the ratio of body length to anteroposterior length, and the ratio of body length to maximum height between the case and control groups. Reductions in the variables of rostrum width, splenium width, body width, the ratio of body width to anteroposterior length, and the ratio of body width to maximum height were significant in both case and control groups (P<0.05). Only the reduction in splenium width was significantly associated with the occurrence of MS (P<0.009, odds ratio [OR]=2.35, 95% confidence interval [CI]=4.51-1.22).
Conclusion: There was no relationship between the morphometric changes of reduced corpus callosum and the changes in IL-6, IL-10 (-819), and IL-10 (-1082) genotypes in patients with MS.
Saeed Kokly , Omid Momen , Omid Kor , Seyyed-Mohsen Hosseininejad ,
Volume 27, Issue 1 (3-2025)
Abstract
Background and Objective: Adhesive capsulitis is one of the most common shoulder disorders, particularly in diabetic patients, and its treatment has been challenging. Adhesive capsulitis begins with a gradual increase in shoulder pain, spontaneous onset, and limitation of active and passive movements of the glenohumeral joint in all directions. In 90% of cases, it responds to conservative treatment; however, if there is no symptomatic improvement after 3-6 months of conservative treatment, surgical treatment, including arthroscopic or open capsular release, should be considered. The current study aimed to compare the efficacy of non-surgical and arthroscopic treatments on shoulder function and pain in diabetic patients with adhesive capsulitis.
Methods: This quasi-experimental study was conducted on 48 diabetic patients (16 males and 32 females; mean age: 53.56±15.93 years) with adhesive capsulitis referring to the orthopedics clinic of 5th Azar Educational and Therapeutic Center in Gorgan, Iran during 2021-2022. Initially, patients were placed under the supervision of shoulder fellowship for conservative treatment for 3 months, and patients without any clinical improvement and with resistant to conservative treatments after 6 months were included in the study. Patients were voluntarily decided to be assigned to one of two treatment groups: Non-surgical (conservative treatment) and arthroscopic surgical (arthroscopic shoulder release). The functional outcomes and limitations of shoulder movement of patients were compared based on the disabilities of the arm, shoulder, and hand (DASH) score in the pre-test and after 3 and 6 months of intervention. The data were presented using descriptive statistical indices. Then, the functional outcomes and limitations of shoulder movement were evaluated.
Results: The mean shoulder function score 3 and 6 months after the intervention was lower in the arthroscopic release surgery group (45.80±19.32 and 43.10±14.12) than in the conservative treatment group (67.89±17.46 and 72.10±15.16) (P<0.05). The mean and standard deviation of symptom scores, such as pain, burning, weakness, and stiffness of the shoulder, 3 and 6 months after the intervention were lower in the arthroscopic release surgery group (12.70±5.66 and 10.02±4.06) than in the conservative treatment group (19.83±8.17 and 21.14±9.37) (P<0.05).
Conclusion: The decreased shoulder function and symptom severity at 3 and 6 months after the intervention was more effective in the arthroscopic release surgery group than in the conservative treatment group.
Marzieh Noshirvanpour Kochaksaraie , Hossain Arabzadeh , Masoumeh Habibian ,
Volume 27, Issue 3 (10-2025)
Abstract
Background and Objective: Vitamin D deficiency is highly prevalent among obese individuals, with multiple underlying mechanisms contributing to this condition. This study aimed to determine the combined effects of high-intensity interval training (HIIT) and vitamin D supplementation on the levels of inflammatory markers, transforming growth factor beta 1 (TGF-β1) and tumor necrosis factor alpha (TNF-α), in young women with vitamin D deficiency.
Methods: In this clinical trial, 39 sedentary women with vitamin D deficiency were randomly assigned to three groups: A control group, a HIIT-based running group, and a combined group (training + vitamin D). The training program included 12 one-minute repetitions of running at 80% to 90% of maximum heart rate (HRmax) and one minute of active rest at 50% HRmax, performed three sessions per week. Vitamin D supplementation was used weekly at a dose of 50,000 IU. TGF-β1 and TNF-α levels were measured and compared before and after the intervention.
Results: After 8 weeks of HIIT-based running, with and without vitamin D supplementation, the levels of inflammatory markers, TGF-β1 and TNF-α, showed a statistically significant decrease compared to the control group (P<0.05). The mean percentage change in TGF-β1 and TNF-α was also significantly greater in the combined group than in the training group without vitamin D supplementation (P<0.05).
Conclusion: Following 8 weeks of HIIT-based running, both inflammatory markers, TGF-β1 and TNF-α decreased in the study subjects, and this reduction was more pronounced in the vitamin D-receiving group.
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