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Showing 2 results for Shahrani
Farbood Y, Sarkaki Ar, Shahrani Korrani M, Saadatfard M,
Volume 18, Issue 2 (6-2016)
Abstract
Background and Objective: Alzheimer's disease is an age-related disease that is characterized by dementia and loss of neurons in the brain. It has been shown that brain oxidative stress plays an important role in aging and neurodegenerative disorders. This study was done to evaluate the effect of grape seed extract (GSE) on memory impairment induced by intracerebroventricular (ICV) injection of streptozotocin (STZ) in animal model of Alzheimer's disease.
Methods: In this experimental study, Eighty adult male Wistar rats were randomly allocated into control, sham, grape seed extract (100 mg/kg/bw, 30 days, orally) plus STZ and STZ plus grape seed extract. Animals memory were evaluated using Morris water maze, shuttle box and T maze tests.
Results: Intracerebroventricular injection of STZ caused memory corruption in all tests. Administration of GSE before and after of administration of intracerebroventricular STZ in the Morris water maze test, significantly reduced latency to get to the hidden platform compared to Alzheimer's group (P<0.05). The latency to enter the dark compartment in passive avoidance memory test significantly increased in compare to animal model of Alzheimer's disease (P<0.05). The selection of the right arm of the T-maze test in animals that received grape seed extract before and after of STZ injection significantly increased compared to animal model of Alzheimer's disease(P<0.05).
Conclusion: Grape seed extract has important effect in prevention and improving memory impairment induced by intracerebventricular injection of STZ.
Saeed Shahrani , Mohammad Rabiei ,
Volume 27, Issue 4 (12-2025)
Abstract
Background and Objective: Genu varum is one of the most prevalent postural deformities resulting from the deviation of the knee alignment from its natural state. This study was conducted to investigate the effects of eight weeks of conventional corrective exercises and corrective games on agility, power, and dynamic balance in male students with genu varum.
Methods: This field trial was conducted on 42 male students, aged 10–13 years, with genu varum in Koohrang County, Chaharmahal and Bakhtiari Province, Iran, during the 2021–2022 academic years. Genu varum was diagnosed using a caliper based on a femoral intercondylar distance exceeding 2 cm. Participants were assigned via a simple randomization method into three groups (n = 14 per group): A control group (no intervention), a conventional corrective exercises group (a selected program consisting of 7 exercises), and a corrective games group (a selected program consisting of 4 games). Agility, power, and dynamic balance variables were assessed using the 4×9 m shuttle run, Sargent jump, and Y-balance tests during the pre-test and post-test phases, respectively.
Results: The degree of genu varum correction in the corrective games group (10.57±4.18 mm) was significantly higher than that of the conventional corrective exercises group (5.43±2.65 mm) (P<0.05). Indicators of agility, power, and dynamic balance of the dominant lower limb showed significant statistical improvement in both the conventional corrective exercise and corrective games groups compared to the control group (P<0.05). However, no significant statistical difference was observed between the two groups regarding the improvement rate of these indicators.
Conclusion: While both conventional corrective exercise and corrective game interventions led to a relative reduction in genu varum deformity, the degree of improvement was significantly more pronounced in the corrective games intervention.
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