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Background and Objective: Femoral shaft traumatic fracture is one of the major causes of mortality and morbidity. Nowadays,the standard treatment method in adult is reduction with femoral interlocking intramedullary nailing. This study was performed to compare the open and closed methods femoral interlocking intramedullary nailingin femoral shaft fractures treatment. Materials and Methods: This clinical trial study was done on 40 18-50 year old patients (33 men and 7 women with mean age of 26.3 years) with femoral shaft closed fracture who were referred to the Shahid Kamyab hospital of Mashhad, Iran during 2007-08. Patients were divided into two 20 membered groups of open and close femoral interlocking intramedullary nailing treatment. Subjects were followed for one year and the :::::union::::: time, infection and non-:::::union::::: level were measured. Clinical and radiological findings were analyzed using SPSS-13, Student’s t-test and Fisher's exact test. Results: 97.5% of :::::union::::: was obtained within six months in both groups. Full weight bearing was determined 6-12 weeks (mean of 9.3 weeks) in close and 12-16 weeks (mean of 13.25 weeks) in open reduction. Complications included non-:::::union::::: in open (one patient, 5%), infection in open (one patient, 5%), shortening in both (one patientin, 5%), limited range of movement in both (one patient, 5%) and malrotation in close (one patient, 5%) groups. Close reduction group showed higher rate of radiologic callus formation and earlier full weight bearing than open reduction group (P<0.005), but :::::union::::: rate was not significant. Conclusion: This study showed that there is no difference between final :::::union::::: rate of open and close reduction by interlocking intramedullary nailing in femoral shaft fractures.

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Background and Objective: Obesity presented as the most pivotal public health problem. Motivational interviewing is a client-centered and direct technique to improve intrinsic motivation of people to change behavior using search and resolve ambivalence that its beneficial outcomes have widely been confirmed. This study was carried out to evaluate the effect of motivational interviewing on weight loss in women. Methods: In this randomized clinical trial study, 150 women with overweight and obesity were randomly divided into control, motivational interviewing and motivational interviewing and intention implementation groups. Data were collected through a researcher made questionnaire at baseline and 2 month follow up. Results: The score of protection motivation theory constructs including susceptibility, severity, rewards, self-efficacy, response efficacy and cost were significantly increased in the two intervention groups compared to the control group (P<0.05). Anthropometric characteristics were significantly reduced in the motivational interviewing and motivational interviewing with intention implementation group (P<0.05) in compare to the control group (P<0.05). Conclusion: Motivational interviewing integrated into intention implementation causes weight loss and increase the constructs score in women.

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Background and Objective: Ducrosia anethifolia (Dc.) is a medicinal odor plant contains CNS effective compounds which has been used in Iranian traditional medicine. This study was done to determine the effect of Ducrosia anethifolia (Dc.) Boiss essential oil on spatial learning and memory in adult male rats.

Methods: In this experimental study, 35 wistar adult male rats were randomly allocated into the five groups (n=7) including: control, sham (injected vehicle) and Ducrosia anethifolia (Dc.) Boiss essential oil groups 0.125, 0.25 and 0.5ml/kg/bw, intraperitonally during four days. Morris water maze test was used to assess learning and memory.

Results: Ducrosia anethifolia (Dc.) Boiss essential oil (0.5 ml/kg/bw) was significantly increased escape latency in the second and third (P<0.05) as well as forth (P<0.05) days of acquisition test in compare to control group. In addition latency to find the hidden platform was significantly decreased with 0.25 essential oil in all days except first day (P<0.05) and in essential oil- treated rats at 0.125 ml/kg/bw in the second and third days (P<0.05) in compare to the control group.  Time spent and distance travelled in target zone were significantly increased in Ducrosia anethifolia (Dc.) Boiss essential oil -treated rats (0.5ml/kg/bw) in compare to control group (P<0.05).

Conclusion: Intraperental administration of the Ducrosia anethifolia (Dc.) Boiss essential oil at doses of 0.5 and 0.25 ml/kg/bw during four days can improves spatial learning and memory in adult male rats.

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Obsessive-compulsive disorder is manifested by a group of symptoms including intrusive thoughts, rituals, mental obsessions and compulsions which creates great distress for the individual. Traumatic brain injurie known as one of the rare reasons of obsessive-compulsive disorder. This report is about 3 patients that suffer from obsessive-compulsive disorder after a traumatic brain injury and loss of consciousness. All 3 patients had no sign of obsessive-compulsive disorder before the trauma. Information on these reports, examine the relationship between obsessive-compulsive disorder and traumatic brain injury. Findings from the neuroimaging methods for these patients have been reported. In this study, all the reported cases that had sever traumatic brain injuries were assessed by neuroimaging methods and brain injuries were obsereved in the right temporal in first case, in the right temporal and both frontal sides in second case, in the splenium corpus callosum and the right brain tegmentums and diffused axonal injury and extra-axial hematoma in the left temporal lobein the thirtd patient. Based on the findings of this study obsessive-compulsive disorder can rarely be developed after a traumatic brain injury and by assessing the neuroimaging findings, we can conclude that there is a relationship between the brain injuries and the symptoms of obsessive-compulsive.

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Background and Objective: Curcumin is a combination of active polyphenol from the Curcuma Langa plant, which has extensive biological activities including effects anti-inflammatory, anti-bacterial and cytotoxic markers for multiple cancer cells. Berberine is an alkaloied isokinolin that is present in berberine and suppresses the growth of many tumor cells. This study was designed to determine the antibacterial effect of berberine and indium curcumin and indium diastile curcumin complexes against E-coli and Bacillus pumilus and comparison of their cytotoxicity on the cell lines of the bladder and stomach cancer cells.
Methods: In this descriptive-analytic study, antimicrobial activity and cytotoxicity effect of berberine and indium curcumin and indium diastile curcumin complexes was investigated by MTT and dilution test method respectively. E-coli [BL21 (DE 3)], Bacillus pumilus (PTCC 1529), cell lines of bladder (5637) and stomach (AGS) were evaluated.
Results: The minimum inhibitory concentration (MIC) of berberin for E-coli was determined 5 mM. At 100 micromolar concentration of berberine approximately 100% of the bladder cancer cells have disappeared. Cytotoxic effect of curcumin complexes on two bladder and stomach cancer cell lines showed that both complexes have different inhibitory effects on cell line life. Cytotoxicity of 20μM indium curcumin and indium diastile curcumin complexes for bladder cancer cells were 58% and 55%, respectively, and for stomach cancer cells were 61% and 34 %, respectively. Antibacterial activity of complexes against Bacillus pumilus and E-coli showed that none of the complexes has antimicrobial effect against Bacillus Pamilus, but both complexes inhibited the growth of E-coli bacteria. The bacteria population in the presence of indium curcumin and indium diastile curcumin complexes was reduced to 40% and 24%, respectively.
Conclusion: This study indicated that indium complexes of curcumin and diacetyl curcumin have a potential for anticancer and antibacterial therapy. Furthermore, berberine as an alkaloid has anticancer and antibacterial activity.