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Background and Objective: Lead as an environmental pollutant can damage the immune system. This study was done to determine the effect of moderate-intensity exercise and Curcumin supplement on serum level of immunoglobulin A in rats exposed to lead acetate. Methods: In this experimental study, 46 male rats were allocated into six groups including Control (C), vehicle (V), lead (L), lead and exercise (LE), lead and curcumin (LC), Lead+exercise+curcumin (LEC). Animals in training groups ran on treadmill for 8 weeks (25- 64 minutes per daily, 15-22 meter/minute and 0% grade). Animals in Lead, LE, LC and LEC groups were received lead acetate (20 mg/kg/bw) and vehicle animals were received ethyl oleat (30 mg/kg/bw) Intraperitoneally for 3 days per week for 8 weeks. Rats in curcumin and LEC groups were received Curcumin (30mg/kg/bw), for 3 day per week for 8 weeks. IgA level were measured by single radial immuno diffusion method. Results: Lead acetate significantly increased MDA levels at P<0.05 in animals. IgA level was 0.2, 0.41 and 0.47 mg/dL in Lead, LE and LEC groups (P<0.05). Conclusion: The simultaneous use of endurance exercise training and curcumin due to increased IgA activity has beneficial effects against lead poisoning.

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Background and Objective: The kidney has a key role in homeostatic regulation. Vascular endothelial growth factor (VEGF) is essential regulator of stimulatory and inhibitory processes for neonatal, post-natal endothelial cell differentiation. This study was done to determine the effect of maternal swimming during pregnancy on VEGF level of kidney in rat pups. Methods: In this experimental study, sixteen Wistar rat dams were allocated into interventional swimming and control groups. In the first day of pregnancy, in interventional group, swimming was performed for 30 minutes a day and 5 minutes every day was added until the time of training gradually reached to one hour per workout. Dams swimming endurance training were performed in 5 days per week for three weeks. Pups’ kidneys were removed two days after birth and kindney tissue VEGF level was determined using ELISA method. Results: Kidney tissue VEGF level in interventional swimming group (133.13 pg/ml) was significantly increased in compared to controls (48.19 pg/ml) (P<0.05). Conclusion: Swimming endurance training increases the pups’ kidney VEGF level.

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Background and Objective: People with asthma are at increased risk for cardiovascular disease and increased risk of death. Asthma is associated with the structure and function of vessel changes. In this regard, MicroRNAs, AKT and VCAM play an important role in endothelial function. So, the aim of this study was to investigate the effect of 12 weeks of interval training on expression of mir-126, mir-1185 AKT and VCAM in cardiac tissue rats with allergic asthma.
Methods: This experimental study was performed on 15 Wistar rats. Animals were randomly allocated into three groups (n=5) including healthy control, asthma control and asthmatic interval training. Ovalbumin solution was injected subcutaneously 3 times per week to asthma groups, and suffering from asthma was confirmed by increasing the amount of IgE. The asthma group participated in 8-week exercise training. The rats were anesthetized at the end of 8 weeks and then their heart tissue was isolated by surgical instrument and immediately placed in nitrogen fluid. Expression of mir-126, mir-1185, AKT and VCAM in rats cardiac tissue were evaluated.
Results: AKT and VCAM expression was significantly increased in asthma control group compared to healthy control group (P<0.05). mir-126, AKT and VCAM expression were significantly increased in asthmatic interval training group in compared to asthma control group (P<0.05) while Mir-1185 was significantly reduced in asthmatic interval training group in compared to asthma control group (P<0.05).
Conclusion: Interval training by increasing mir-126, by reducing the expression of mir-1185, AKT, and VCAM reduces the risk of atherosclerosis in rats affected with asthma.