Journal of Gorgan University of Medical Sciences
مجله علمي دانشگاه علوم پزشكي گرگان
J Gorgan Univ Med Sci
Medical Sciences
http://goums.ac.ir/journal
59
journal58
1562-4765
2008-4080
10.61882/goums
fa
jalali
1387
9
1
gregorian
2008
12
1
10
4
online
1
fulltext
fa
اثر درمانی آزیترومایسین بر لیشمانیوز جلدی
Efficacy of azithromycin in the treatment of cutaneous leishmaniasis
عمومى
General
تحقيقي
Original Articles
<h1 dir="rtl" style="TEXT-JUSTIFY: kashida MARGIN: 0cm 14.1pt 0pt 14.2pt PAGE-BREAK-AFTER: auto TEXT-INDENT: 11.35pt TEXT-ALIGN: justify TEXT-KASHIDA: 0% mso-pagination: none"><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"><p></p></span></h1>
<p dir="rtl" style="font-style:normal;"><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"><span><p></p></span></span></p>
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<p dir="rtl" style="font-style:normal;"><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"><span><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Zar mso-bidi-language: FA mso-no-proof: yes">زمینه و هدف :</span><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt"> </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">درمان لیشمانیوز جلدی با داروهای خوراکی، ارزان، بی</span></i><i><span lang="FA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-FAMILY: Lotus mso-bidi-language: FA"></span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">ضرر و با تحمل بالا </span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">به </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">شدت مورد توجه قراردارد. این مطالعه با هدف بررسی اثربخشی آزیترومایسین </span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">ب</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">ر درمان لیشمانیوز جلدی در </span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">اهواز</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt"> انجام شد.<p></p></span></i></span></span></p>
<p dir="rtl" style="font-style:normal;"></p>
<p style="font-style:normal;"><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"><span><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Zar mso-no-proof: yes"> </span></span></span></p>
<p dir="rtl" style="font-style:normal;"><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"><span><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Zar mso-bidi-language: FA mso-no-proof: yes">روش بررسی:</span><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"> در این </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">کارآزمائی بالینی تصادفی کنترل شده 28 بیمار مبتلا به لیشمانیوز جلدی</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"> </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">(گروه</span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"> درمان</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">) و</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"> </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">26 بیمار </span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">به عنوان</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt"> گروه </span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">شاهد</span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt"> </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">در یک کلینیک تخصصی بیماری</span></i><i><span lang="FA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-FAMILY: Lotus mso-bidi-language: FA"></span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">های عفونی و گرمسیری شهر اهواز</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"> </span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">طی </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">اردیبهشت1385 تا مهر 1386</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"> </span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">بررسی شدند. </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">آزیترومایسین ب</span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">ه</span></i><i><span lang="FA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-FAMILY: Lotus mso-bidi-language: FA"></span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">مقدار 500 میلی</span></i><i><span lang="FA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-FAMILY: Lotus mso-bidi-language: FA"></span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">گرم یک</span></i><i><span lang="FA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-FAMILY: Lotus mso-bidi-language: FA"></span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">بار در روز ب</span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">ه</span></i><i><span lang="FA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-FAMILY: Lotus mso-bidi-language: FA"></span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">مدت 28 روز به بیماران گروه </span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">درمان </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">داده شد.</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"> </span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">در گروه شاهد بیماران دارویی دریافت نکردند. </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">هر دو</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"> </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">گروه در روزهای</span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"> 14 و 28 </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">و ماه</span></i><i><span lang="FA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-FAMILY: Lotus mso-bidi-language: FA"></span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">های 2و5 از نظر وضعیت زخم پیگیری شدند. داده</span></i><i><span lang="FA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-FAMILY: Lotus mso-bidi-language: FA"></span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">ها در نرم</span></i><i><span lang="FA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-FAMILY: Lotus mso-bidi-language: FA"></span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">افزا</span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">ر </span></i><font face="Times New Roman"><i><span dir="ltr" style="FONT-SIZE: 8pt mso-bidi-language: FA mso-bidi-font-size: 10.0pt mso-bidi-font-family: Lotus">SPSS</span></i><span dir="rtl"></span></font><i><span style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"><span dir="rtl"></span> </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">و</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"> </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">با استفاده ا</span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">ز آزمون</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt"> دقیق فیشر و</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"> </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">مجذور کای تجزیه و تحلیل شدند.<p></p></span></i></span></span></p>
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<p style="font-style:normal;"><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"><span><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Zar mso-bidi-language: FA mso-no-proof: yes"> </span></span></span></p>
<p dir="rtl" style="font-style:normal;"><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"><span><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Zar mso-bidi-language: FA mso-no-proof: yes">یافتهها :</span><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"> </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">میانگین سنی بیماران</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"> </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">45/8</span></i><span dir="ltr"></span><i><span dir="ltr" style="FONT-SIZE: 8pt mso-bidi-font-size: 10.0pt mso-bidi-font-family: Lotus"><span dir="ltr"></span><font face="Times New Roman">±</font></span></i><span dir="rtl"></span><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt"><span dir="rtl"></span>26/20 سال و</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"> </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">نسبت سنی مذکر به مؤنث 5/1 به 1 بود.</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"> </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">نیمی از بیماران ساکن مناطق روستائی بودند. در پایان درمان 13نفر</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"> </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">(4/46</span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">درصد</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">) </span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">از</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt"> گروه درمان و</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"> </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">4نفر</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"> </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">(4/15</span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">درصد</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">) </span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">از</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt"> گروه شاهد بهبود یافتند</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">(P<0.02)</span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">. </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">فقط یک مورد عود در گرو</span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">ه </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">درمان</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"> </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">دیده شد</span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">،</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt"> ولی عارضه داروئی جدی و</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"> </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">قابل توجهی دیده نشد.<p></p></span></i></span></span></p>
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<p style="font-style:normal;"><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"><span><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Zar mso-bidi-language: FA mso-no-proof: yes"> </span></span></span></p>
<p dir="rtl" style="font-style:normal;"><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"><span><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Zar mso-bidi-language: FA mso-no-proof: yes">نتیجهگیری:</span><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">این مطالعه نشان داد که </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">آزیترومایسین در</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"> </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">درمان بیماران مبتلا به لیشمانیوز جلدی اثرات قابل قبولی دارد و</span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"> </span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">از آن می</span></i><i><span lang="FA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-FAMILY: Lotus mso-bidi-language: FA"></span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">توان </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">ب</span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">ه </span></i><i><span lang="AR-SA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-ansi-font-size: 8.0pt">عنوان داروی جانشین </span></i><i><span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt">استفاده نمود.<p></p></span></i></span></span></p>
<span lang="FA" style="FONT-SIZE: 10pt FONT-FAMILY: Lotus mso-bidi-language: FA mso-ansi-font-size: 8.0pt"><p></p></span><p></p>
Background and Objective: Treatment of Cutaneous leishmaniasis (CL) with oral therapeutic drugs, ideally cheap, with good tolerance and safe are highly desirable.The aim of this study was to assess the efficacy of azithromycin (AZ) for treatment of patients with CL in Ahvaz – Iran. Materials and Methods: In a randomized controlled clinical trial study, 28 patients with CL as cases (AZ group) and 26 patients as control (C group) were studied. Cases were treated orally 500 mg/day of azithromycin in single dose for 28 days. Patients in control group did not receive any treatment. Both groups were followed up in days 14, 28 and month 2 and 5. Data were analyzed in SPSS-11.5 by using chi square and exact Fisher's tests. Results: Means±SD age of subjects was 20.26±8.45 years. Male to female ratio was 1.5:1. The half of the patients resided in rural area. At the end of study treatment. 46.4% of patients in AZ group and 15.4% of patients in control group were cured (P<0.02). One relapse of CL was observed in AZ group, no serious drug side effects was observed. Conclusion: This study showed that azithromycin has an acceptable effect on the treatment of cutaneous leishmaniasis in Iranian patients and can be used alternatively in treatment of cutaneous leishmaniasis.
لیشمانیوز جلدی , آزیترومایسین
Cutaneous leishmaniasis, Azithromycin, Iran
1
5
http://goums.ac.ir/journal/browse.php?a_code=A-10-1-324&slc_lang=fa&sid=1
Seyyed Mohammad Alavi (MD)
سید محمد
علوی
5900319475328460047638
5900319475328460047638
Yes
Leila Alavi (VMD)
لیلا
علوی
5900319475328460047639
5900319475328460047639
No